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1.

State-selective modulation of heterotrimeric Gαs signaling with macrocyclic peptides.

Dai, Shizhong A; Hu, Qi; Gao, Rong; Blythe, Emily E; Touhara, Kouki K; Peacock, Hayden; Zhang, Ziyang; von Zastrow, Mark; Suga, Hiroaki; Shokat, Kevan M.

Cell ; 185(21): 3950-3965.e25, 2022 10 13.

Artículo en Inglés | MEDLINE | ID: mdl-36170854

2.

Membrane phosphoinositides regulate GPCR-ß-arrestin complex assembly and dynamics.

Janetzko, John; Kise, Ryoji; Barsi-Rhyne, Benjamin; Siepe, Dirk H; Heydenreich, Franziska M; Kawakami, Kouki; Masureel, Matthieu; Maeda, Shoji; Garcia, K Christopher; von Zastrow, Mark; Inoue, Asuka; Kobilka, Brian K.

Cell ; 185(24): 4560-4573.e19, 2022 11 23.

Artículo en Inglés | MEDLINE | ID: mdl-36368322

3.

Mechanisms for Regulating and Organizing Receptor Signaling by Endocytosis.

von Zastrow, Mark; Sorkin, Alexander.

Annu Rev Biochem ; 90: 709-737, 2021 06 20.

Artículo en Inglés | MEDLINE | ID: mdl-33606955

4.

The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders.

Willsey, A Jeremy; Morris, Montana T; Wang, Sheng; Willsey, Helen R; Sun, Nawei; Teerikorpi, Nia; Baum, Tierney B; Cagney, Gerard; Bender, Kevin J; Desai, Tejal A; Srivastava, Deepak; Davis, Graeme W; Doudna, Jennifer; Chang, Edward; Sohal, Vikaas; Lowenstein, Daniel H; Li, Hao; Agard, David; Keiser, Michael J; Shoichet, Brian; von Zastrow, Mark; Mucke, Lennart; Finkbeiner, Steven; Gan, Li; Sestan, Nenad; Ward, Michael E; Huttenhain, Ruth; Nowakowski, Tomasz J; Bellen, Hugo J; Frank, Loren M; Khokha, Mustafa K; Lifton, Richard P; Kampmann, Martin; Ideker, Trey; State, Matthew W; Krogan, Nevan J.

Cell ; 174(3): 505-520, 2018 07 26.

Artículo en Inglés | MEDLINE | ID: mdl-30053424

5.

An Approach to Spatiotemporally Resolve Protein Interaction Networks in Living Cells.

Lobingier, Braden T; Hüttenhain, Ruth; Eichel, Kelsie; Miller, Kenneth B; Ting, Alice Y; von Zastrow, Mark; Krogan, Nevan J.

Cell ; 169(2): 350-360.e12, 2017 04 06.

Artículo en Inglés | MEDLINE | ID: mdl-28388416

6.

ß-Arrestin-independent endosomal cAMP signaling by a polypeptide hormone GPCR.

Blythe, Emily E; von Zastrow, Mark.

Nat Chem Biol ; 20(3): 323-332, 2024 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-37749347

7.

Profiling the proximal proteome of the activated µ-opioid receptor.

Polacco, Benjamin J; Lobingier, Braden T; Blythe, Emily E; Abreu, Nohely; Khare, Prachi; Howard, Matthew K; Gonzalez-Hernandez, Alberto J; Xu, Jiewei; Li, Qiongyu; Novy, Brandon; Naing, Zun Zar Chi; Shoichet, Brian K; Coyote-Maestas, Willow; Levitz, Joshua; Krogan, Nevan J; Von Zastrow, Mark; Hüttenhain, Ruth.

Nat Chem Biol ; 2024 Mar 25.

Artículo en Inglés | MEDLINE | ID: mdl-38528119

8.

Sequence-dependent sorting of recycling proteins by actin-stabilized endosomal microdomains.

Puthenveedu, Manojkumar A; Lauffer, Benjamin; Temkin, Paul; Vistein, Rachel; Carlton, Peter; Thorn, Kurt; Taunton, Jack; Weiner, Orion D; Parton, Robert G; von Zastrow, Mark.

Cell ; 143(5): 761-73, 2010 Nov 24.

Artículo en Inglés | MEDLINE | ID: mdl-21111236

9.

Gαs is dispensable for ß-arrestin coupling but dictates GRK selectivity and is predominant for gene expression regulation by ß2-adrenergic receptor.

Burghi, Valeria; Paradis, Justine S; Officer, Adam; Adame-Garcia, Sendi Rafael; Wu, Xingyu; Matthees, Edda S F; Barsi-Rhyne, Benjamin; Ramms, Dana J; Clubb, Lauren; Acosta, Monica; Tamayo, Pablo; Bouvier, Michel; Inoue, Asuka; von Zastrow, Mark; Hoffmann, Carsten; Gutkind, J Silvio.

J Biol Chem ; 299(11): 105293, 2023 11.

Artículo en Inglés | MEDLINE | ID: mdl-37774973

10.

Catalytic activation of ß-arrestin by GPCRs.

Eichel, Kelsie; Jullié, Damien; Barsi-Rhyne, Benjamin; Latorraca, Naomi R; Masureel, Matthieu; Sibarita, Jean-Baptiste; Dror, Ron O; von Zastrow, Mark.

Nature ; 557(7705): 381-386, 2018 05.

Artículo en Inglés | MEDLINE | ID: mdl-29720660

11.

An expanded palette of dopamine sensors for multiplex imaging in vivo.

Patriarchi, Tommaso; Mohebi, Ali; Sun, Junqing; Marley, Aaron; Liang, Ruqiang; Dong, Chunyang; Puhger, Kyle; Mizuno, Grace Or; Davis, Carolyn M; Wiltgen, Brian; von Zastrow, Mark; Berke, Joshua D; Tian, Lin.

Nat Methods ; 17(11): 1147-1155, 2020 11.

Artículo en Inglés | MEDLINE | ID: mdl-32895537

12.

Spatial decoding of endosomal cAMP signals by a metastable cytoplasmic PKA network.

Peng, Grace E; Pessino, Veronica; Huang, Bo; von Zastrow, Mark.

Nat Chem Biol ; 17(5): 558-566, 2021 05.

Artículo en Inglés | MEDLINE | ID: mdl-33649598

13.

A high-throughput CRISPR interference screen for dissecting functional regulators of GPCR/cAMP signaling.

Semesta, Khairunnisa Mentari; Tian, Ruilin; Kampmann, Martin; von Zastrow, Mark; Tsvetanova, Nikoleta G.

PLoS Genet ; 16(10): e1009103, 2020 10.

Artículo en Inglés | MEDLINE | ID: mdl-33052901

14.

Endosomal cAMP production broadly impacts the cellular phosphoproteome.

Tsvetanova, Nikoleta G; Trester-Zedlitz, Michelle; Newton, Billy W; Peng, Grace E; Johnson, Jeffrey R; Jimenez-Morales, David; Kurland, Andrew P; Krogan, Nevan J; von Zastrow, Mark.

J Biol Chem ; 297(1): 100907, 2021 07.

Artículo en Inglés | MEDLINE | ID: mdl-34166681

15.

When trafficking and signaling mix: How subcellular location shapes G protein-coupled receptor activation of heterotrimeric G proteins.

Lobingier, Braden T; von Zastrow, Mark.

Traffic ; 20(2): 130-136, 2019 02.

Artículo en Inglés | MEDLINE | ID: mdl-30578610

16.

Proteomic Approaches to Investigate Regulated Trafficking and Signaling of G Protein-Coupled Receptors.

von Zastrow, Mark.

Mol Pharmacol ; 99(5): 392-398, 2021 05.

Artículo en Inglés | MEDLINE | ID: mdl-33361190

17.

Endocytosis and signalling: intertwining molecular networks.

Sorkin, Alexander; von Zastrow, Mark.

Nat Rev Mol Cell Biol ; 10(9): 609-22, 2009 Sep.

Artículo en Inglés | MEDLINE | ID: mdl-19696798

18.

Open science takes on the coronavirus pandemic.

Zastrow, Mark.

Nature ; 581(7806): 109-110, 2020 05.

Artículo en Inglés | MEDLINE | ID: mdl-32332909

19.

Coronavirus contact-tracing apps: can they slow the spread of COVID-19?

Zastrow, Mark.

Nature ; 2020 May 19.

Artículo en Inglés | MEDLINE | ID: mdl-32433633

20.

South Korea is reporting intimate details of COVID-19 cases: has it helped?

Zastrow, Mark.

Nature ; 2020 Mar 18.

Artículo en Inglés | MEDLINE | ID: mdl-32203363

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State-selective modulation of heterotrimeric Gαs signaling with macrocyclic peptides.

Membrane phosphoinositides regulate GPCR-ß-arrestin complex assembly and dynamics.

Mechanisms for Regulating and Organizing Receptor Signaling by Endocytosis.

The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders.

An Approach to Spatiotemporally Resolve Protein Interaction Networks in Living Cells.

ß-Arrestin-independent endosomal cAMP signaling by a polypeptide hormone GPCR.

Profiling the proximal proteome of the activated µ-opioid receptor.

Sequence-dependent sorting of recycling proteins by actin-stabilized endosomal microdomains.

Gαs is dispensable for ß-arrestin coupling but dictates GRK selectivity and is predominant for gene expression regulation by ß2-adrenergic receptor.

Catalytic activation of ß-arrestin by GPCRs.

An expanded palette of dopamine sensors for multiplex imaging in vivo.

Spatial decoding of endosomal cAMP signals by a metastable cytoplasmic PKA network.

A high-throughput CRISPR interference screen for dissecting functional regulators of GPCR/cAMP signaling.

Endosomal cAMP production broadly impacts the cellular phosphoproteome.

When trafficking and signaling mix: How subcellular location shapes G protein-coupled receptor activation of heterotrimeric G proteins.

Proteomic Approaches to Investigate Regulated Trafficking and Signaling of G Protein-Coupled Receptors.

Endocytosis and signalling: intertwining molecular networks.

Open science takes on the coronavirus pandemic.

Coronavirus contact-tracing apps: can they slow the spread of COVID-19?

South Korea is reporting intimate details of COVID-19 cases: has it helped?